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血浆内皮素（ＥＴ）是血管内皮细胞分泌的，由２１个氨基酸组成的具有强烈缩血管作用的活性肽，其与心血管系统在生理和病理方面的关系已受到广泛关注。近年来有研究表明，肝脏可能与ＥＴ的产生和清除有着较密切的关系。用ＥＴ灌注鼠肝可导致肝内胆汁的淤滞［１］，由此推测黄
Plasma endothelin (ET) is a 21-amino acid active peptide secreted by vascular endothelial cells, which has a strong vasoconstrictor activity. It has drawn much attention in the physiological and pathological aspects of the cardiovascular system. In recent years, studies have shown that the liver may have a closer relationship with the production and clearance of ET. Rat liver perfusion with ET can lead to intrahepatic bile stasis [1], suggesting that yellow