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1926及1931年Von Willebrand在芬兰海岸外Aland岛上发现一个家族,在66个成员中有23人得出血性疾病。这种出血性疾病不同于传统的血友病,出血时间延长,当时称为遗传性假血友病。1933年Willebrand及Jürgens用血栓检验器(Thrombometer)测定血小板功能,认为此病的血小板功能异常,故又称为先天性血小板病。1953年Alexander等人指出这类病人除了出血时间延长外,还缺乏抗血友病球蛋白(简称AHG)。1960年以后,不少
In 1926 and 1931 Von Willebrand found a family on the island of Aland off the coast of Finland, with 23 out of 66 members having blood disorders. This hemorrhagic disease is different from the traditional hemophilia, prolonged bleeding time, then known as hereditary hemophilia. 1933 Willebrand and Jürgens thrombometer (Thrombometer) platelet function, that the disease is abnormal platelet function, it is also known as congenital thrombocytopathies. In 1953 Alexander et al. Pointed out that these patients in addition to prolonged bleeding, but also the lack of anti-hemophilia globulin (AHG). After 1960, quite a few