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目的观察半夏泻心口服液对乙醇及脱氧胆酸钠诱发实验性慢性胃炎的治疗作用。方法以乙醇及脱氧胆酸钠诱发实验性慢性胃炎模型后,用不同剂量半夏泻心口服液对模型进行治疗,以得乐胶囊作对照;疗程结束后,用光镜观察胃粘膜组织学变化,并在NYD-1000型图像分析仪上测量粘膜肌厚度,再进行统计分析。结果半夏泻心口服液高剂量组炎症变化、腺体萎缩、粘膜肌增厚各项积分均较其余各组为少(P<0.01)粘膜肌厚度较其余各组薄(P<0.01)。结论半夏泻心口服液对实验性慢性胃炎有肯定的治疗作用。
Objective To observe the therapeutic effect of Banxia Xiexin Oral Liquid on ethanol and sodium deoxycholate induced experimental chronic gastritis. Methods The model of experimental chronic gastritis induced by ethanol and sodium deoxycholate was treated with different doses of Banxia Xiexin Oral Liquid. The Dele capsule was used as a control. After the end of treatment, the histological changes of gastric mucosa were observed by light microscope. The mucous muscle thickness was measured on a NYD-1000 image analyzer and statistical analysis was performed. Results The scores of inflammatory changes, glandular atrophy and mucosal muscle thickening in the high dose group of Banxia Xiexin Oral Liquid were lower than those in the other groups (P<0.01). The thickness of mucosal muscle was thinner than other groups (P<0). .01). Conclusion Banxia Xiexin Oral Liquid has a positive therapeutic effect on experimental chronic gastritis.