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目的 :探讨哮喘儿柯萨奇B组病毒 (CVB)感染对IgE的影响。方法 :4 0例哮喘儿 ,年龄 3～ 12岁 ;肺炎儿4 9例作为对照组 ,年龄 2～ 12岁。以ELISA法检测CVB ,以比浊法测定血清IgE。结果 :CVB感染率 :哮喘感染率为 6 2 .5 0 % (2 5 / 4 0 ) ,肺炎感染率 4 0 .82 % (2 0 / 4 9) ,哮喘儿的CVB感染率高于同期住院肺炎儿 (P <0 .0 5 ) ;哮喘儿的IgE水平明显高于肺炎组 (P <0 .0 5 ) ;有CVB感染的哮喘儿 2 5例 ,IgE水平 (6 4 9.0 6 4±394 .5 5 0 )IU/ml;无CVB感染的哮喘儿 15例 ,IgE水平 (35 3.80 0± 2 5 5 .94 2 )IU/ml,两者比较有明显的差异 (P<0 .0 5 )。有CVB感染的肺炎 10例 ,IgE水平 (30 0 .818± 2 91.12 8)IU/ml;无CVB感染的哮喘儿 13例 ,IgE水平 (2 0 9.84 5± 2 2 1.84 9)IU/ml,两者比较无差异 (P >0 .0 5 )。但CVB的阳性效价与IgE水平无线性相关关系。结论 :在小儿哮喘中有高的CVB感染率 ,并与哮喘儿的IgE变化有明显的关联。在哮喘病儿要重视预防CVB感染。
Objective: To investigate the effect of Coxsackie B virus (CVB) infection on IgE in asthmatic children. Methods: 40 asthmatic children aged 3 to 12 years and 49 children with pneumonia were selected as control group, aged 2 to 12 years old. CVB was detected by ELISA and serum IgE was measured by turbidimetry. Results: The infection rate of CVB was 62.5% (25/40) for asthma and 40.82% (20/49) for pneumonia. The CVB infection rate in asthmatic children was higher than that in the same period of hospitalization (P <0.05). IgE levels in asthmatic children were significantly higher than those in pneumonia group (P <0.05). Twenty-five asthmatic children with CVB infection had IgE levels of 64 904 ± 394 (P <0.05). There were 15 cases of asthma without CVB infection and IgE level (35 3.80 0 ± 25 5 .94 2) IU / ml with significant difference (P <0.05) ). 10 cases of CVB-infected pneumonia, IgE level (30 0 .818 ± 2 91.12 8) IU / ml; 13 cases of CVB-free asthma, IgE level of 2 0 9.84 5 ± 2 2 1.84 9 IU / ml, There was no difference between the two (P> 0.05). However, there is no linear relationship between the positive titer of CVB and IgE level. Conclusions: There is a high CVB infection rate in pediatric asthma and a clear association with changes in IgE in asthmatic children. Children with asthma should pay attention to prevent CVB infection.