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目的 探讨单纯疱疹病毒 (HSV)感染与冠心病心肌梗死的关系。方法 测定 51例急性心肌梗死 (AMI)和 42例陈旧性心肌梗死(OMI)患者及 31例冠脉造影正常者 (NC)的HSV 1抗体、纤维蛋白原 (Fg)、6 酮 前列环素F1α(6 Keto PGF1α)、血栓素B2 (TXB2 )水平。结果 AMI组HSV 1IgG阳性率及水平高于NC组 (P <0 .0 5) ,HSV 1DNA检测结果与之吻合。校正冠心病危险因素前、后 ,HSV 1IgG阳性与AMI均有相关关系 (OR 4 .2 66 ,P =0 .0 1 9;OR 3 .32 1 ,P =0 .0 32 )。AMI组中HSV 1 (+)组Fg、TXB2 高于 ,而 6 Keto PGF1α低于同组中HSV 1 (- )组 (均P <0 .0 1 ) ;且IgG与TXB2 呈正相关 ,与 6 Keto PGF1α呈负相关 ,调整冠心病的危险因素前、后 ,IgG与Fg均呈正相关。 结论 HSV 1感染与AMI之间存在明显的相关性 ,与Fg、TXB2 及 6 Keto PGF1α也存在相关性。
Objective To investigate the relationship between herpes simplex virus (HSV) infection and myocardial infarction in patients with coronary heart disease. Methods 51 cases of acute myocardial infarction (AMI) and 42 cases of old myocardial infarction (OMI) and 31 cases of coronary angiography (NC) HSV 1 antibody, fibrinogen (Fg), 6 ketone prostaglandin F1α (6 Keto PGF1α), thromboxane B2 (TXB2) levels. Results The positive rate and level of HSV 1 IgG in AMI group were higher than those in NC group (P <0.05). The results of HSV 1 DNA test were consistent with those of NC group. HSV 1IgG positivity correlates with AMI before and after the correction of risk factors for coronary heart disease (OR 4 .2 66, P = .0 1 9; OR 3 .32 1, P = .0 32). Fg and TXB2 in HSV 1 (+) group were higher than AMI group, while 6 Keto PGF1α was lower than HSV 1 (-) group in the same group (all P <0.01); IgG and TXB2 were positively correlated with 6 Keto PGF1α was negatively correlated, before and after adjusting for the risk factors of coronary heart disease, IgG and Fg were positively correlated. Conclusions There is a significant correlation between HSV 1 infection and AMI, and there is also correlation with Fg, TXB2 and 6 Keto PGF1α.