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目的探讨经皮穿刺引流术治疗重症急性胰腺炎对患者炎症因子的影响,为胰腺炎临床治疗提供理论依据。方法 30例重症急性胰腺炎患者,将患者分为观察组(17例)和对照组(13例)。两组患者均采用常规的基础治疗,观察组患者在此治疗基础上行经皮穿刺引流术,对照组患者在此基础上行常规保守治疗。比较两组患者治疗后腹痛缓解情况、术后住院时间、血淀粉酶恢复正常时间及白细胞介素6(IL-6)、白细胞介素8(IL-8)、肿瘤坏死因子(TNF)的变化情况。结果治疗后,观察组腹痛缓解时间为(3.4±0.2)d、住院时间为(12.2±3.3)d、血淀粉酶恢复时间为(2.3±0.5)d,均短于对照组的(5.9±0.7)、(20.5±4.6)、(5.1±1.8)d,差异均有统计学意义(P<0.05);治疗后观察组IL-6、IL-8及TNF水平低于对照组,差异有统计学意义(P<0.05)。结论相对于常规保守治疗,经皮穿刺引流术治疗重症胰腺炎有较好的临床效果,能显著降低患者炎症反应,促进患者康复,值得临床推广。
Objective To investigate the effect of percutaneous drainage on inflammatory factors in patients with severe acute pancreatitis and provide a theoretical basis for the clinical treatment of pancreatitis. Methods Thirty patients with severe acute pancreatitis were divided into observation group (17 cases) and control group (13 cases). The two groups of patients were treated with routine basic treatment. The patients in the observation group underwent percutaneous drainage on the basis of this treatment. The patients in the control group underwent routine conservative treatment. The pain relief, postoperative hospital stay, serum amylase recovery time and the changes of IL-6, IL-8 and TNF were compared between the two groups Happening. Results After treatment, the pain relief time was (3.4 ± 0.2) d in the observation group, (12.2 ± 3.3) days in the observation group and (2.3 ± 0.5) days in the amylase, which were shorter than that in the control group (5.9 ± 0.7 ), (20.5 ± 4.6) and (5.1 ± 1.8) d, respectively (all P <0.05). The levels of IL-6, IL-8 and TNF in the observation group after treatment were lower than those in the control group Significance (P <0.05). Conclusion Compared with conventional conservative treatment, percutaneous drainage for the treatment of severe pancreatitis has a better clinical effect, can significantly reduce the patient’s inflammatory response and promote patient rehabilitation, is worthy of clinical promotion.