Antiulcer activity of methanolic extract and fractions of Picralima nitida seeds(Apocynacaea) in rat

• 作 者: Okonta Jegbefume Mathew Adibe Maxwell Ogochukwu Ubaka Chukwuemeka Michael
• 机 构: Department of Clinical Pharmacy and Pharmacy Management,Faculty of Pharmaceutical Sciences,Universit
• 出 处: Asian Pacific Journal of Tropical Medicine
• 发表日期: 2011年01期
• 关键词: methanol chloroform emptying saline fractionated administration ligation secreti

Objective:To investigated the antisecrectory activities of the methanol extract,chloroform fraction and methanol fraction of Picralima nitida seeds.Methods:The methanol extract of Picralima nitida seeds was fractionated into chloroform fraction and methanol fraction.They were evaluated for antiulcer activity and gastric emptying time in rats using aspirin-pylorus-ligation model.Results:Oral administration of the methanol extract,chloroform fraction and methanol fraction at 1 000 mg/kg reduced gastric ulcer by 56.4%,40.0%and 56.3%,respectively;and the fractions of the extract significantly(P<0.05) reduced gastric emptying time when compared to the control.Gastric acidity was significandy decreased when compared with saline group,40.25 mEq/ L in methanol extract,50.0 mEq/L in chloroform fraction 51.25 mEq/L in methanol fration but had no significant effect on the gastric secretion volume.Conclusions:These findings showed that methanol extract,chloroform fraction and methanol fraction of the seeds of Picralima possessed potent antiulcer properties and some antisecretory properties.

Objective: To investigated the antisecrectory activities of the methanol extract, chloroform fraction and methanol fraction of Picralima nitida seeds. Methods: The methanol extract of Picralima nitida seeds was fractionated into chloroform fraction and methanol fraction. They were evaluated for antiulcer activity and gastric emptying time in rats using aspirin-pylorus-ligation model. Results: Oral administration of the methanol extract, chloroform fraction and methanol fraction at 1 000 mg / kg reduced gastric ulcer by 56.4%, 40.0% and 56.3%, respectively; and the fractions of the Lysine fraction 51.25 mEq / L in methanol fraction (P <0.05) reduced gastric emptying time when compared to the control. Gastric acidity was significantly reduced compared to saline group, 40.25 mEq / L in methanol extract, 50.0 mEq / L in methanol fraction but had no significant effect on the gastric secretion volume. Conclusions: These findings showed that methanol extract, chloroform fraction and methanol fraction of the seeds of Picralima possessed potent antiulcer properties and some antisecretory properties.