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活性炭为一有效的非特异性吸附剂。大量实验证明,活性炭不仅能抑制药物的吸收,还能促进其清除;临床已试用于多种药物过量中毒、毒物的吸附、以及其它疾病的治疗。本文将近几年来国内外临床上应用研究活性炭的情况综述如下。 1.用于地高辛中毒 Halodonde给10名受试者静脉输注地高辛作随机交叉研究,并采用放射免疫法测定地高辛血药浓度,10名受试者在口服活性炭后地高辛的清除(Cl)由每小时12.2±2.0((?)±SD)增加到18.0±2.9 L,平均增加47%。稳态分布容积(Vd_(ss))减少24%,自495±196减少到375±162 L,消除半减期(t_(1/2)β)自36.5±11.8缩短为21.5±6.5小
Activated carbon is an effective non-specific adsorbent. A large number of experiments show that activated carbon can not only inhibit the absorption of drugs, but also promote their clearance; clinical trial has been used for a variety of drug overdose, poison absorption, and other diseases. In this paper, the clinical application of activated carbon at home and abroad in recent years are summarized as follows. 1 for digoxin poisoning Halodonde 10 subjects intravenous infusion of digoxin for randomized cross-over study, and radioimmunoassay determination of digoxin plasma concentration, 10 subjects after oral administration of activated carbon high The clearance of Cl increased from 12.2 ± 2.0 (± SD) per hour to 18.0 ± 2.9 L with an average increase of 47%. The steady-state volume of distribution (Vd ss) decreased 24% from 495 196 to 375 162 L and the half-life (t 1/2 1/2) was reduced from 36.5 11.8 to 21.5 6.5