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先天性甲状腺功能低下,造成的后果为不可逆的智能低下和身材矮小,早期治疗能避免症状发生。故甲低的早期诊断至关重要:但因先天性甲低早期往往缺乏特征性临床表现.新生儿期大规模筛查是解决本病早期诊断的唯一途径,以脐带血中的垂体促甲状腺激素(TSH)含量作为检测指标,筛查先天性甲低症目前已普遍开展,并被认为是一种可靠手段,但由于(TSH)分子的a-链与垂体促黄体激素(LH),促卵泡激素(FSH)和绒毛膜促性腺激素(HCG)的α-链结构相似,在测定时容易出现交叉反应,新生儿脐带血中的LH、FSH、HCG含量较高时,可能对TSH的结果产生影响出现假阳性。故我们对新生儿脐带血中LH,FSH、HCG的含量进行测定,以期了解其基础水平,并运用统计学方法比较了它们与脐带血纸片标本中TSH测定值的相关关系。新生儿脐带血中LH的含量为29.69±14.41IU/L(n=96),FSH为1.62±1.9IU/L(n=96),HCG为100.99±84.94IU/L(n=93)。脐带血纸片标本TSH
Congenital hypothyroidism, the consequences of irreversible mental retardation and short stature, early treatment to avoid symptoms. However, the early diagnosis of hypothyroidism is very important: but congenital hypothyroidism often lack of characteristic clinical manifestations.Neft-stage large-scale screening is the only way to solve the early diagnosis of this disease to umbilical cord blood thyroid stimulating hormone (TSH) as a detection index screening for congenital hypothyroidism has now been widely carried out and is considered to be a reliable means, but due to (a TSH) chain and pituitary luteinizing hormone (LH), follicle stimulating The structure of α-chain of hormone (FSH) and human chorionic gonadotropin (HCG) is similar. Cross-reaction appears easily in the measurement. The result of TSH may be produced when the contents of LH, FSH and HCG in neonatal cord blood are high Impact of false positives. Therefore, we measured the contents of LH, FSH and HCG in the umbilical cord blood of newborns in order to understand its basic level, and used statistical methods to compare their correlation with the TSH values in umbilical cord blood samples. The neonatal umbilical cord blood levels of LH were 29.69 ± 14.41 IU / L (n = 96), FSH was 1.62 ± 1.9 IU / L (n = 96) and HCG was 100.99 ± 84.94 IU / L (n = 93). Umbilical cord blood specimen TSH