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目的:评价~(131)碘对甲状腺功能亢进伴重症肝损害患者肝功能指标的改善情况。方法:选取2012年10月—2014年12月间收治的甲状腺功能亢进伴重症肝损害患者30例的临床资料,分析治疗前后的肝功能指标及体征改善情况,以及游离三碘甲状原氨酸(FT3)和甲状腺素(FT4)水平。结果:治疗后肝功能各指标以及甲状腺激素水平改善情况优于治疗前(P<0.05);治疗6月后患者肝功能各指标和甲状腺激素水平的改善情况优于治疗3月的疗效(P<0.05)。结论:采用~(131)碘治疗甲状腺功能亢进伴重症肝损害患者,疗效改善显著,用药安全和有效。
Objective: To evaluate the improvement of liver function index of ~ (131) iodine in patients with hyperthyroidism and severe liver damage. Methods: The clinical data of 30 patients with hyperthyroidism and severe liver damage who were admitted from October 2012 to December 2014 were selected. The changes of liver function indexes and signs before and after treatment were analyzed. The levels of free triiodothyronine ( FT3) and thyroxine (FT4) levels. Results: The indicators of liver function and the improvement of thyroid hormones were better than those before treatment (P <0.05). After 6 months of treatment, the indexes of liver function and thyroid hormone levels were better than those of March (P < 0.05). Conclusion: 131I treatment of hyperthyroidism with severe liver damage in patients with significant improvement in efficacy, safe and effective medication.