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目的探讨食管癌单纯放疗和食管癌体外高频热疗配合放射治疗的疗效。方法 80例初治食管鳞癌患者随机分成单纯放疗组和放疗联合体外高频热疗组(简称热放组)。放疗组:2Gy/F,5F/W,总剂量60Gy;热放组:放射方法同放疗组,只是在放疗前或后1h内给予瘤床区体外高频热疗60min,每周2次。观察指标为食管的近期急性反应、无瘤生存率和总生存率。结果热放组总生存率和无瘤生存率均高于单纯放疗组,但差异无统计学意义(P>0.05)。热放疗组的急性反应较轻,Ⅲ级食管炎、放射性气管炎的发生率与单纯放疗组比较,差异无统计学意义(P>0.05)。结论放疗联合体外高频热疗治疗食管癌,患者耐受性好,减轻了急性反应;能明显提高1～5年无瘤生存率和总生存率。
Objective To investigate the curative effect of simple radiotherapy esophageal cancer and esophageal cancer in vitro high frequency hyperthermia combined with radiotherapy. Methods 80 cases of newly diagnosed esophageal squamous cell carcinoma patients were randomly divided into radiotherapy group and radiotherapy combined with external high frequency hyperthermia group (referred to as heat release group). Radiotherapy group: 2Gy / F, 5F / W, the total dose of 60Gy; heat release group: radiotherapy method with radiotherapy group, only given within 1h before radiotherapy or tumor bed in vitro high frequency hyperthermia 60min, 2 times a week. The observation indicators for the recent esophageal acute response, tumor-free survival and overall survival. Results The total survival rate and tumor-free survival rate were significantly higher in radiotherapy group than in radiotherapy alone group, but the difference was not statistically significant (P> 0.05). There was no significant difference between the two groups (P> 0.05). There was no significant difference in the incidence of grade Ⅲ esophagitis and radiation bronchitis between radiotherapy group and radiotherapy alone group. Conclusion Radiotherapy combined with high frequency hyperthermia in vitro treatment of esophageal cancer, patients with good tolerance, reduce the acute response; can significantly improve the 1 to 5 years disease-free survival and overall survival.