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目的：观察抑癌基因 ｐ１６，ｐ２１ 及 ｐ５３ 在鼻咽癌（ Ｎ Ｐ Ｃ）的表达，探讨其与 Ｎ Ｐ Ｃ的发生发展及预后的关系。方法：用免疫组化 Ｓ Ｐ法检测了 １１６ 例 Ｎ Ｐ Ｃ 组织和 １５ 例无瘤鼻咽（ Ｎ Ｐ）组织的 ｐ１６，ｐ２１ 及 ｐ５３ 基因的表达情况。结果：① Ｎ Ｐ Ｃ 组中 ｐ１６，ｐ２１，ｐ５３ 阳性率分别为６４．７％ ，４５．７％ 和９０．５％ ；与 Ｎ Ｐ组比较，差异均有统计学意义（ Ｐ＜ ０．０５）。②ｐ１６ 在 Ｎ Ｐ Ｃ非角化型阳性率为７０．６％ ，未分化型阳性率为４４．８％ ，两者有显著性差异（ Ｐ＜ ０．０５）。③ｐ２１ 与 ｐ１６，ｐ５３ 阳性表达之间有相关性。结论：ｐ１６，ｐ２１ 的低表达与 Ｎ Ｐ Ｃ 的发生密切相关，ｐ１６ 异常表达与细胞分化程度有一定关系，ｐ１６ 与 ｐ２１ 在 Ｎ Ｐ Ｃ的发生发展中存在协同作用；ｐ２１ 可能不是通过野生型 ｐ５３ 的刺激途径产生
OBJECTIVE: To observe the expression of tumor suppressor genes p16, p21 and p53 in nasopharyngeal carcinoma (NPC) and to explore their relationship with the occurrence, development and prognosis of N P C. Methods: The expressions of p16, p21 and p53 in 116 cases of Npc tissue and 15 cases of non-tumorous nasopharynx (NP) tissues were detected by immunohistochemical SP method. Results: ① The positive rates of p16, p21 and p53 in N P C group were 64.7%, 45.7% and 90.5%, respectively, which were significantly different from those in N P group (P <0.05 ). ② The positive rate of p16 in N P C non-keratinized type was 70.6%, and the positive rate of undifferentiated type was 44.8%. There was a significant difference between the two (P <0.05). ③ There is a correlation between p21 and p16, p53 positive expression. Conclusion: The low expression of p16 and p21 is closely related to the occurrence of N P C. The abnormal expression of p16 is related to the degree of cell differentiation. There is a synergistic effect between p16 and p21 in the development and progression of N P C; p21 may not be detected by wild type p53 Stimulation pathway generated