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目的观察锎252中子刀联合体外照射治疗I，II期原发性阴道癌的副反应发生情况。方法选取我院2009年1月~2012年12月收治的I，II期原发性阴道癌患者30例，对所有患者采用锎252中子刀联合体外照射方法进行治疗，观察副反应发生情况。结果于治疗后的3年内发生的副反应情况为：5例发生重度的直肠炎，13例发生轻度的放射性直肠炎，4例发生轻度的放射性膀胱炎。结论锎252中子刀联合体外照射治疗 I，II期原发性阴道癌疗效可靠、安全方便，可有效维持患者的正常功能，但近期副反应发生率较高。“,”Objective: Observation of side ef ects of CF 252neutron knife combined with external irradiation for the treatment of I,II primary vaginal cancer incidence. Methods:in our hospitalin 2009 January-2012 year in December from I,II in patients with primary vaginal carcinoma 30 cases,treatment for al patients withCF 252 neutron knife combined with external irradiation method,to observe the adverse reaction. Results:the adverse reactionsafter treatment occurred within 3 years:5 cases with severeproctitis,radiation proctitis occurred in 13 cases,mild,4 cases had mild radiation cystitis. Conclusion:CF 252 neutron knifecombined with external irradiation for the treatment of I,II primaryvaginal cancer curative ef ect is reliable,safe and convenient,which can ef ectively maintain the normal function of patients,but recently the incidence of side ef ects of higher.