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三硝基甲苯(TNT)在Ames,小白鼠骨髓微核及染色体畸变试验中均具有明显的致突变作用,但其在人体有无诱变性至今尚不明确。本文就82例TNT作业工人外周血淋巴细胞微核变化规律作一分析,以期较全面地评价TNT的细胞遗传学效应和微核检测系统在化学诱变物职业监测中的意义。对象与方法一、对象接触组为近期未进行放射治疗、服特殊药物及接触其它毒物的82名包头矿务局化工厂混合、装药和防
Trinitrotoluene (TNT) has obvious mutagenic effects in Ames, mouse bone marrow micronuclei and chromosome aberration test, but its mutagenicity in the human body is still not clear. In this paper, 82 cases of TNT workers micronucleus changes in peripheral blood lymphocytes for an analysis of a more comprehensive assessment of the cytogenetic effect of TNT and micronucleus detection system in the chemical mutagen occupational monitoring significance. Subjects and methods First, the object contact group for the recent no radiation therapy, taking special drugs and other toxic substances exposed 82 Baotou Mining Bureau chemical plant mixing, charging and anti