论文部分内容阅读
IL-1通过胞膜 G 蛋白激活 cAMP、IP_3等第二信使系统,进而活化一系列蛋白激酶,将信息传递至细胞核,通过活化 AP-1位点或胞核中原有的 NF-~kB 分子,最终实现基因转录。
IL-1 activates the second messenger system such as cAMP and IP_3 through the membrane G protein, then activates a series of protein kinases to transmit the information to the nucleus. Through activation of the original NF-κB molecule in AP-1 locus or nucleus, Ultimately achieve gene transcription.