论文部分内容阅读
HLA 复合体为位于人第6号染色体短臂上的基因群,其编码分子在细胞表面,对抗原物质的自我—非我识别有重要性(图1):细胞表面分子有两类:一类由 HLA—A、HLA—B 和 HLA—C 基因决定的称Ⅰ类分子,它是由分子量45,000的重链非共价地联结分子量12,000的轻链即β_2微球蛋白而组成。HLA—A、HLA—B 和 HLA—C 位点构成Ⅰ类重链基因,而β_2微球蛋白的编码受控于第15染色体。Ⅰ类分子的作用与识别靶细胞有关,它存在于 T 细胞亚类,常用表面标记 T(?)表示,这样的细胞通常与抑制性 T 细胞和细胞毒性 T 细胞(包括杀伤病毒感染的靶细胞)
The HLA complex is a gene cluster located on the short arm of human chromosome 6 and encodes molecules on the cell surface that are important for the self-non-recognition of antigenic substances (Figure 1). There are two types of cell surface molecules: Class I molecules, which are determined by HLA-A, HLA-B and HLA-C genes, are composed of non-covalently linked heavy chains with a molecular weight of 12,000, β 2 microglobulin, of a heavy chain of 45,000. HLA-A, HLA-B and HLA-C sites form class I heavy chain genes, whereas β 2 microglobulin is encoded by chromosome 15. Class I molecules are involved in the identification of target cells and are present in T-cell subsets and are commonly referred to as surface-labeled T (?). Such cells are usually associated with inhibitory T cells and cytotoxic T cells, including killer virus-infected target cells )