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目的探讨痰嗜酸粒细胞增高与慢性阻塞性肺疾病(COPD)加重期糖皮质激素疗效的关系。方法选取COPD加重期患者69例,均行强的松30 mg/d口服至10 d,治疗前后行痰诱导嗜酸细胞计数、肺功能检查,根据初次痰嗜酸粒细胞增高与否将病例分为两组,采用统计学方法比较两组患者治疗前后肺功能变化。结果在糖皮质激素治疗后,痰嗜酸粒细胞增高组较非增高组肺功能明显改善。结论诱导痰进行嗜酸粒细胞检查对于COPD加重期患者是否选用糖皮质激素治疗具有参考价值。
Objective To investigate the relationship between sputum eosinophilia and the effect of glucocorticoid in exacerbation of chronic obstructive pulmonary disease (COPD). Methods Sixty-nine patients with COPD exacerbation were enrolled in this study. All patients were given prednisone 30 mg / d orally for 10 days. Phlegm-induced eosinophil counts and pulmonary function tests were performed before and after treatment. According to whether initial sputum eosinophilia was increased or not, For the two groups, using statistical methods to compare the two groups of patients before and after treatment of lung function changes. Results After glucocorticoid treatment, sputum eosinophilia significantly improved lung function compared with non-increased group. Conclusion Induction sputum for eosinophil examination for patients with exacerbation of COPD is glucocorticoid therapy has reference value.