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Objective: We hypothesized that umbilical vein serum soluble fms-like tyrosine kinase 1 (sFlt1) concentration was augmented in preeclampsia. We also explored a possible association between fetal and maternal concen-trations of sFlt1. Study design: At cesarean delivery, maternal serum samples from preeclamptic (n = 38) and uncomplicated (n = 32) pregnancies were obtained, as well as umbilical vein serum and amniotic fluid samples. ELISA for human sFlt1, vascular endothelial growth factor (VEGF) and placental growth factor (PlGF)were performed. Results: Median sFlt1 concentrations were elevated in preeclampsia compared to uncomplicated pregnancy, in umbilical venous serum (246 and 163 pg/mL, P = 0.04), in maternal serum (9932 and 3417 pg/mL, P < 0.001), as well as in amniotic fluid (51,040 and 33,490 pg/mL, P = 0.03). A positive association between the fetal and maternal serum levels of sFlt1 was found in the preeclampsia group. Median PlGF concentration in the maternal serum was significantly lower in the preeclampsia group compared to the control group (82 pg/mL and 169 pg/mL, P < 0.001). Conclusions: sFlt1 concentration is elevated in the fetal circulation in preeclampsia, but at a much lower level than in the maternal circulation. The results of our study do not support a substantial fetal contribution to the elevated circulating maternal sFlt1 protein concentration in preeclampsia.
Objective: We hypothesized that umbilical vein serum soluble fms-like tyrosine kinase 1 (sFlt1) concentration was augmented in preeclampsia. We also explored a possible association between fetal and maternal concen-trations of sFlt1. Study design: At cesarean delivery, maternal serum samples ELISA for human sFlt1, vascular endothelial growth factor (VEGF) and placental growth factor (PlGF) were performed Results: Median sFlt1 concentrations were elevated in preeclampsia compared to uncomplicated pregnancy, in umbilical venous serum (246 and 163 pg / mL, P = 0.04), in maternal serum (9932 and 3417 pg / mL, as in amniotic fluid (51,040 and 33,490 pg / mL, P = 0.03). A positive association between the fetal and maternal serum levels of sFlt1 was found in the preeclampsia group. Median PlGF concentration in the maternal serum was signifi cantly lower in the preeclampsia group compared to the control group (82 pg / mL and 169 pg / mL, P <0.001). Conclusions: sFlt1 concentration is elevated in the fetal circulation in preeclampsia, but at a much lower level than in the maternal The results of our study do not support a substantial fetal contribution to the elevated circulating maternal sFlt1 protein concentration in preeclampsia.