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To examine whether screening guidelines for gestational diabetes should be modified based on ethnicity. Study design: This is a retrospective cohort study of 14,565 pregnancies screened for gestational diabetes. The primary outcome of interest was the diagnosis of gestational diabetes based on the results of the 100g glucose tolerance test. A diagnosis was determined if any 2 of the 4 values (fasting or 1- , 2- , or 3- hour postprandial) were at or above 95, 180, 155, or 140 mg/dL, respectively. Values of the 50 g glucose-loading test were examined from 130 mg/dL to 150 mg/dL. The sensitivity, specificity, false- positive rates, and positive predictive values of various glucose-loading test cut-offs were compared among whites, African Americans, Latinas, and Asians. The sensitivities and specificities were compared using receiver-operator characteristic curves. Results: Sensitivity and specificity of the glucose-loading test differ by ethnicity. Generally, African Americans achieved the highest sensitivities and specificities over the range examined. To achieve a false-positive rate of 10% for the glucose-loading test, the threshold value would be 133 mg/dL for African Americans, 140 mg/dL for whites, 143 mg/dL for Latinas, and 147 mg/dL for Asians. At the lower glucose-loading test values (130 and 135 mg/dL), Asians exhibited the highest positive predictive values (30.0% and 34.0% ), whereas at higher values of the glucose-loading test (145 and 150 mg/dL), African Americans had the highest positive predictive values (46.0% and 51.5% ). Throughout the glucose-loading test range, whites had the lowest positive predictive values (P < .001). Conclusions: To maximizethe sensitivity and minimize the false-positive rate of the glucose-loading test, it may be reasonable to consider varying the threshold based on ethnicity. However, modification of glucose-loading test thresholds based on maternal ethnicity merit further study to determine whether improved perinatal outcomes can be achieved.
To examine whether screening guidelines for gestational diabetes should be modified based on ethnicity. Study design: This is a retrospective cohort study of 14,565 pregnancies screened for gestational diabetes. The primary outcome of interest was the diagnosis of gestational diabetes based on the results of the 100g A diagnosis was determined if any 2 of the 4 values (fasting or 1-, 2-, or 3-hour postprandial) were at or above 95, 180, 155, or 140 mg / dL, respectively. Values of the sensitivity, specificity, false-positive rates, and positive predictive values of various glucose-loading test cut-offs were compared among whites, African Americans , Latinas, and Asians. The sensitivities and specificities were compared using receiver-operator characteristic curves. Results: Sensitivity and specificity of the glucose-loading test by by ethnicity. Generally, African Americans achieved th The highest sensitivities and specificities over the range examined. To achieve a false-positive rate of 10% for the glucose-loading test, the threshold value would be 133 mg / dL for African Americans, 140 mg / dL for whites, 143 mg / At the lower glucose-loading test values (130 and 135 mg / dL), Asians exhibited the highest positive predictive values (30.0% and 34.0%), while at higher values of the African Americans had the highest positive predictive values (46.0% and 51.5%). Throughout the glucose-loading test range, whites had the lowest positive predictive values (P <.001) . Conclusions: To maximizethe sensitivity and minimize the false-positive rate of the glucose-loading test, it may be reasonable to consider varying the threshold based on ethnicity. However, modification of glucose-loading test thresholds based on maternal ethnicity merit further study to determine whether improved perinatal outcomes can be achieved.