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利用流式细胞术及免疫荧光双染色法，检测３５例系统性红斑狼疮（ＳＬＥ）患者外周血细胞粘附分子表型（ＣＤ１１ａ、ＣＤ１８、ＣＤ５４）及淋巴细胞表型（ＣＤ３、ＣＤ４、ＣＤ８、ＣＤ４５、ＲＡ、ＣＤ４５ＲＯ）。结果表明，ＳＬＥ活动组ＣＤ８＋细胞增高，ＣＤ４＋ＣＤ４５ＲＡ＋细胞减少；ＣＤ４＋细胞表面ＣＤ１１ａ、ＣＤ１８表达降低，后二者在ＣＤ８＋细胞上表达增高；ＣＤ５４在ＣＤ２０＋细胞上增高。进一步发现，ＣＤ８＋细胞的ＣＤ１８增高与ＣＤ４＋ＣＤ４５ＲＡ＋细胞减少呈负相关（Ｐ＜００５），而与ＣＤ２０＋细胞表面ＣＤ５４增高呈正相关（Ｐ＜００１）。本文提示，细胞粘附分子可能在ＳＬＥ发病机理中占有重要意义。
The expressions of CD11a, CD18, CD54 and lymphocyte phenotypes (CD3, CD4, CD8, CD45) in 35 patients with systemic lupus erythematosus were detected by flow cytometry and immunofluorescence double staining. , RA, CD45RO). The results showed that the number of CD8 + cells increased and the number of CD4 + CD45RA + cells decreased in SLE group. The expression of CD11a and CD18 on CD4 + cells decreased. The expression of CD54 on CD8 + cells increased and CD54 increased on CD20 + cells. It was further found that the increase of CD18 in CD8 + cells was negatively correlated with the decrease of CD4 + CD45RA + cells (P <0.01), but positively correlated with the increase of CD54 in CD8 + cells (P <001). This article suggests that cell adhesion molecules may play an important role in the pathogenesis of SLE.