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目的分析儿童特发性血小板减少性紫癜血清B淋巴细胞激活因子表达情况,为其诊断及预后提供参考依据。方法以2012年9月-2014年6月本院收治的120例初诊为特发性血小板减少性紫癜患儿及60例同期健康体检的正常儿童为研究对象,比较急性型组和慢性型组及正常儿童组血清B淋巴细胞激活因子表达情况、抗血小板抗体PAIg G、PAIg M和PAIg A水平及血小板计数情况。结果急性型组和慢性型组特发性血小板减少性紫癜患儿外周血B淋巴细胞激活因子、PAIg G、PAIg M和PAIg A含量均高于对照组,但是其血小板计数少于对照组,差异均有统计学意义(P均<0.05);其血清B淋巴细胞激活因子含量与PAIg G、PAIg M和PAIg A含量呈正相关,与血小板计数呈负相关,其疗效与BAFF含量也呈负相关。结论特发性血小板减少性紫癜患儿血清中B淋巴细胞激活因子表达增加,且与抗血小板抗体、血小板计数以及治疗效果具有良好的相关性,其可作为该病诊断的参考依据。
Objective To analyze the expression of B lymphocyte activation factor in children with idiopathic thrombocytopenic purpura and to provide a reference for its diagnosis and prognosis. Methods From September 2012 to June 2014, 120 newly diagnosed idiopathic thrombocytopenic purpura patients and 60 normal controls were enrolled in this study. The acute and chronic group were compared. The expression of B lymphocyte activation factor, anti-platelet antibody PAIg G, PAIg M and PAIg A in normal children and the platelet counts. Results The levels of B lymphocyte activation factor, PAIg G, PAIg M and PAIg A in children with acute idiopathic thrombocytopenic purpura and acute idiopathic thrombocytopenic purpura were higher than those in the control group, but the platelet count was lower than that in the control group (P <0.05). There was a positive correlation between the levels of serum B lymphocyte activation factor and the contents of PAIg G, PAIg M and PAIg A, and negatively correlated with the platelet count. The curative effect was also negatively correlated with the level of BAFF. Conclusions Serum B lymphocyte activation factor expression is increased in idiopathic thrombocytopenic purpura patients, and it has a good correlation with antiplatelet antibody, platelet count and therapeutic effect, which may serve as a reference for the diagnosis of this disease.