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目的了解从化地区尖锐湿疣患者HPV基因型别的分布情况,并观察复发与性别、HPV基因型别有无相关性。方法采用PCR-反向点杂交法对163例初发尖锐湿疣患者进行HPV基因检测,并在完全清除疣体后连续观察3个月、6个月,记录有无复发。结果 163例尖锐湿疣患者HPV-DNA阳性率达91.41%,共检测出20种HPV基因类型,比较常见的分别是HPV6(43.62%),HPV 11(41.61%),HPV16(12.75%)和HPV43(10.60%)。低危型HPV检出率为86.58%,高危型HPV检出率为41.61%。男女之间高危型检测率差异有统计学意义(P=0.012)。单一感染发生率(63.76%)高于混合感染(36.24%)。随访3个月时,复发35例,6个月时复发44例。在3个月及6个月时,男女之间、高低危型之间、单一感染与混合感染之间复发率差异均无统计学意义(P>0.05))。结论本地区尖锐湿疣患者以HPV6,11,16型感染为主,尖锐湿疣复发和性别、HPV基因型别无相关性。
Objective To understand the distribution of HPV genotypes in patients with condylomata acuminatum in the Conghua area and to observe whether relapse has any correlation with sex and HPV genotypes. Methods The HPV gene was detected in 163 cases of patients with condyloma acuminatum by PCR-reverse dot blot hybridization. The patients were followed up for 3 months and 6 months after complete wart removal, and the recurrence was recorded. Results The positive rate of HPV-DNA in 163 patients with condyloma acuminatum was 91.41%. Twenty kinds of HPV genotypes were detected. The most common HPV genotypes were HPV6 (43.62%), HPV11 (41.61%), HPV16 10.60%). Low-risk HPV detection rate was 86.58%, high-risk HPV detection rate was 41.61%. There was a significant difference in the detection rate of high-risk type between men and women (P = 0.012). The incidence of single infection (63.76%) was higher than that of mixed infection (36.24%). At follow-up of 3 months, 35 cases relapsed and 44 cases relapsed at 6 months. At 3 months and 6 months, there was no significant difference in recurrence rate between single infection and mixed infection between men and women, between high and low risk type (P> 0.05). Conclusions The patients with genital warts in this area are mainly infected with HPV type 6, 11 and 16. Recurrence of condyloma acuminatum has no correlation with sex and HPV genotype.