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在一项新的研究中,来自美国佐治亚大学和日本东京大学的研究人员鉴定出两种最为常见的骨髓性白血病的一种新的药物靶标,并且找到一种阻止这种疾病的最为侵袭性类型的方法。相关研究结果在线发表在Nature期刊上。通过阻断一种被称作BCAT1的蛋白,这些研究人员能够阻止小鼠体内和来自白血病患者的人血液样品中的癌细胞生长。BCAT1蛋白激活一组被称作支链氨基酸(branched-chain amino acid,BCAA)的氨基酸代谢。BCAA是所有细胞中的必需构成单元,因而是侵
In a new study, researchers from the University of Georgia in the United States and the University of Tokyo in Japan identified a new drug target for two of the most common myeloid leukemias and found one of the most aggressive types to stop the disease Methods. Relevant research results published online in Nature. By blocking a protein called BCAT1, these researchers were able to stop cancer cell growth in human blood samples from mice and leukemia patients in mice. BCAT1 protein activates a group of amino acid metabolism called branched-chain amino acid (BCAA). BCAA is an essential building block in all cells and therefore invading