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传统的活血化瘀药物,按药性有和血、活血及破血之分类,选用代表药物十味,按15g/kg 的剂量给 Wistar 大鼠口服4日(对照组给水)。采用 HAAKE RV100/CV100流变仪等仪器,测定血液粘度、血浆粘度、红细胞比容、红细胞聚集指数、血小板聚集、复钙凝血时间(t_r)以及低切变率下凝血过程中血液粘度上升率(dη/dt)等九项流变学指标。结果表明,上述药物对凝血过程(t_r 及 dη/dt)有一定的规律性影响(P<0.05),其中破血药的抗凝血能力最强。在血液粘度及红细胞聚集指数等指标上,亦表现出随活血化瘀药物之药性增强而下降的趋势。
Traditional medicines for promoting blood circulation and removing blood stasis, according to the classification of drug and blood, blood circulation, and blood stasis, were used to represent ten flavors of drugs and Wistar rats were orally administered at 15 g/kg for 4 days (control group water supply). HAAKE RV100/CV100 rheometer and other instruments were used to measure blood viscosity, plasma viscosity, hematocrit, erythrocyte aggregation index, platelet aggregation, recalcification clotting time (t_r), and blood viscosity increase rate during coagulation under low shear rate ( Nine rheological indicators such as dη/dt). The results showed that the above drugs had a certain regular effect on the coagulation process (t_r and dη/dt) (P<0.05), of which the hemolytic agents had the strongest anticoagulant activity. In terms of blood viscosity and erythrocyte aggregation index, it also showed a tendency to decrease with the enhanced drug properties of blood circulation and stasis drugs.