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Mifepristone(RU486)是一种孕激素受体阻断剂,它能在受体水平抗孕激素和糖皮质激素,而对其他甾体受体的亲和力很小或无,已证明它能干扰人的黄体期和终止早孕而无抗糖皮质激素作用。Epostane(WIN 32729)是一种孕激素合成抑制剂,通过抑制3β—羟基甾体脱氢酶系统从而抑制孕烯醇酮转化为孕酮和抑制脱氢表雄酮转化为雄烯二酮,已证明它能阻断卵巢和胎盘的甾体生成,在对糖皮质激素无明显影响的剂量水平能终止妊娠。本文中作者比较了二种剂量RU486和Epcstane中
Mifepristone (RU486) is a progestin receptor blocker that has low or no affinity for other steroid receptors at the receptor level, progesterone and glucocorticoids and has been shown to interfere with human Luteal phase and termination of early pregnancy without anti-glucocorticoid effect. Epostane (WIN 32729) is a progestin-synthesis inhibitor that inhibits the conversion of pregnenolone to progesterone and inhibits the conversion of dehydroepiandrosterone to androstenedione by inhibiting the 3β-hydroxy steroid dehydrogenase system Prove that it blocks steroidogenesis in the ovaries and placenta, ending the pregnancy at dose levels that do not significantly affect glucocorticoids. The authors compared the two doses RU486 and Epcstane