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目的：探讨ＣＧＲＰ对海马神经元坏死的影响。方法：用ＲＩＡ法测定脑损伤大鼠血浆及海马匀浆中ＣＧＲＰ含量变化。结果：脑损伤组血浆及海马匀浆中ＣＧＲＰ水平在伤后６ｈ明显高于对照组，而在伤后３０ｍｉｎ、２４ｈ及７２ｈ组明显低于对照组，血浆及海马ＣＧＲＰ水平变化与病程有关，且二者具有显著相关性。结论：脑损伤后海马缺血及迟发性神经元坏死与血浆、海马ＣＧＲＰ水平下降有关，动态测定血浆ＣＧＲＰ水平可作为脑损伤后病情发生、发展的评价指标。
Objective: To investigate the effect of CGRP on hippocampal neuron necrosis. Methods: The contents of CGRP in plasma and hippocampus of rats with brain injury were measured by RIA. Results: The level of CGRP in plasma and hippocampus homogenate of brain injury group was significantly higher than that of control group 6h after injury, but was significantly lower than that of control group at 30min, 24h and 72h after injury The two have significant correlation. Conclusion: Hippocampal ischemia and delayed neuronal necrosis after cerebral injury is related to the decrease of CGRP in plasma and hippocampus. The dynamic measurement of plasma CGRP level can be used as an evaluation index for the occurrence and development of brain injury.