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目的探讨一氧化氮（ＮＯ）和氧自由基对淋巴滞留性脑病的影响。方法以Ｗｉｓｔａｒ大鼠为实验动物，通过结扎和摘除颈深淋巴结造成淋巴滞留性脑病的动物模型，测定脑淋巴引流阻断后１，３，５和７ｄ大脑皮层内ＮＯ，脂质过氧化物（ＭＤＡ）和自由基清除剂ＣｕＺｎ－ＳＯＤ含量的动态变化。结果脑淋巴引流阻断后１ｄＮＯ含量明显降低，３、５和７ｄ降低更显著。与对照组比较，１、３、５和７ｄ的ＭＤＡ含量显著增加（Ｐ＜０．０１）而ＣｎＺｎ－ＳＯＤ含量均显著减低（Ｐ＜０．０１）。ＭＤＡ与ＣｕＺｎ－ＳＯＤ有显著负相关（Ｐ＜０．０５）。结论ＮＯ、氧自由基在实验性淋巴滞留性脑病的病理过程中可能起重要作用。
Objective To investigate the effects of nitric oxide (NO) and oxygen free radicals on lymphatic retention encephalopathy. Methods Wistar rats were used as experimental animals. Animal models of lymphatic stagnated encephalopathy caused by ligation and removal of cervical deep lymph nodes were established. The levels of NO and lipid peroxides (LPS) in cerebral cortex at 1, 3, 5 and 7 days after lymphatic drainage were measured. MDA) and free radical scavenger CuZn-SOD content changes. Results The content of NO on the 1st day after cerebral lymphatic drainage was significantly decreased, but decreased more significantly on 3rd, 5th and 7th day. Compared with the control group, the content of MDA increased significantly (P <0.01) and the content of CnZn-SOD decreased significantly on the 1st, 3rd, 5th and 7th day (P <0.01). There was a significant negative correlation between MDA and CuZn-SOD (P <0.05). Conclusion NO, oxygen free radicals may play an important role in the pathological process of experimental lymphocytic encephalopathy.