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目的观察地塞米松联合肠溶阿司匹林预防中重度一氧化碳中毒迟发脑病的临床疗效。方法将100例中重度一氧化碳中毒患者随机分为治疗组(对照组治疗基础上加用地塞米松联合肠溶阿司匹林)和对照组(常规高压氧、防治脑水肿、脑保护治疗),观察患者一氧化碳中毒后第5天、10天、20天、30天、45天、60天。判断是否出现一氧化碳中毒迟发性脑病。结果治疗组50例,出现迟发脑病4例,占8%;对照组50例,出现迟发脑病12例,占24%。两组比较差异有统计学意义(P<0.05)。结论地塞米松联合肠溶阿司匹林治疗中重度一氧化碳中毒,使其迟发脑病发生率较对照组明显降低,取得显著预防效应。
Objective To observe the clinical efficacy of dexamethasone combined with enteric-coated aspirin in the prevention of delayed encephalopathy caused by moderate or severe carbon monoxide poisoning. Methods 100 patients with moderate to severe carbon monoxide poisoning were randomly divided into treatment group (control group treated with dexamethasone combined with enteric-coated aspirin) and control group (conventional hyperbaric oxygen, cerebral edema prevention and treatment, brain protection), observed carbon monoxide poisoning After the fifth day, 10 days, 20 days, 30 days, 45 days, 60 days. To determine whether there is delayed carbon monoxide poisoning encephalopathy. Results In the treatment group, 50 cases showed delayed encephalopathy in 4 cases, accounting for 8%. In the control group, 50 cases showed delayed encephalopathy in 12 cases, accounting for 24%. The difference between the two groups was statistically significant (P <0.05). Conclusion Dexamethasone combined with enteric-coated aspirin in the treatment of moderate-severe carbon monoxide poisoning, the incidence of delayed encephalopathy was significantly lower than the control group, and achieved a significant preventive effect.