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作者等对气管、支气管癌采用喷雾化疗(Nebuli-zation Chemotherapy,NC),获较好效果。方法:将可溶性抗癌剂5-Fu制成微粒,加四丁酚醛(Alevaire)1ml,用超声喷雾吸入,或与溴苄环已铵(Bisoevon)混合经口直接吸入。若肿瘤位于末梢时,嘱患者深吸喷雾液。5-Fu剂量250～500mg/日,分1、2次用,每日用或每周2～3剂,视效果尽可能长期应用。病例分为二组:第1组6例,年龄53～74岁,男2例,女4例,均为一般状态差,不能耐受多剂并用的全身投药法,单独行NC法4例,以NC为主者2例。鳞癌3例(肺门型2例,末梢型1例),腺癌2例(中间型1例,末梢型1例),小细胞癌1例为中间型。第2组6例,年龄58岁～69岁,均为男性NC并用CMAF方案。鳞癌2例(1例肺门型,1例末梢型),余4例为腺癌(肺门型及末梢型各1例,中间型2例)。结果,第1组6例,有效4例,完全有效(Complete response,CR)2例,部分有效(Partial response,PR)2例,余2例因有远位转移,未充分施行本疗法
The authors used nebuli-zation Chemotherapy (NC) for tracheal and bronchial cancer with good results. Methods: The soluble anticancer agent 5-Fu was made into microparticles, 1 ml of tetrahydrofolate (Alevaire) was added, and it was inhaled with ultrasonic spray or mixed with Bisoevon and inhaled directly. If the tumor is located at the tip, the paralyzed patient takes a deep spray. 5-Fu dose 250 ~ 500mg / day, 1 or 2 times, daily or weekly 2 to 3 doses, depending on the effect as long as possible application. Cases were divided into two groups: Group 1 in 6 patients, aged 53 to 74 years old, 2 males and 4 females, all of whom were in poor general condition and could not tolerate the combination of multiple doses of systemic administration. Two cases were based on NC. There were 3 cases of squamous cell carcinoma (2 cases of hilar, 1 case of peripheral type), 2 cases of adenocarcinoma (1 case of intermediate type, 1 case of peripheral type), and 1 case of small cell carcinoma was intermediate type. The second group consisted of 6 patients, aged 58 to 69 years old, all of whom were male NCs and used the CMAF protocol. There were 2 cases of squamous cell carcinoma (1 case of hilar and 1 type of peripheral) and 4 cases of adenocarcinoma (1 case of hilar and peripheral type and 2 cases of intermediate type). Results: The first group was 6 cases, 4 cases were effective, 2 cases were complete response (CR), 2 cases were partial response (PR), and the remaining 2 cases were not fully implemented due to distant metastasis.