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目的：观察青霉胺和甲氨蝶呤联合治疗类风湿关节炎疗效。方法：试验分２组，治疗组７０例（男性１３例，女性５７例；年龄４７±ｓ１２ａ；病程３±４ａ）在原有非甾体抗炎镇痛药的基础上用青霉胺１２５ｍｇ／片，ｐｏ，ｑｄ和甲氨蝶呤７．５ｍｇ，ｐｏ，ｑｗ；对照组５５例（男性１７例，女性３８例；年龄５１±１２ａ；病程６±５ａ）只应用非甾体抗炎镇痛药。２组均３ｍｏ为一个疗程。结果：治疗组总有效率９４％，显效率６７％；对照组总有效率７６％，显效率９％，Ｐ＜０．０１。不良反应依次为１７％和１３％。结论：联合药物治疗的效果好。
Objective: To observe the efficacy of penicillamine and methotrexate in the treatment of rheumatoid arthritis. Methods: The experiment was divided into two groups, the treatment group of 70 patients (13 males and 57 females; age 47 ± s12a; duration of 3 ± 4a) on the basis of the original non-steroidal anti-inflammatory analgesic penicillamine 125mg / tablet , Po, qd and methotrexate 7.5mg, po, qw; control group of 55 patients (17 males and 38 females; age 51 ± 12a; duration of 6 ± 5a) only non-steroidal anti-inflammatory analgesics . 2 groups were 3mo for a course of treatment. Results: The total effective rate was 94% and the effective rate was 67% in the treatment group. The total effective rate in the control group was 76% and the effective rate was 9% (P <0.01). Adverse reactions followed by 17% and 13%. Conclusion: The effect of combined drug treatment is good.