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目的:观察复方硫酸沙丁胺醇气雾剂联合氨溴索、地塞米松雾化吸入治疗AECOPD患者疗效(AECOPD是指慢性阻塞性肺气肿急性加重期)。方法:选择同期64例慢性阻塞性肺气肿急性加重期患者,随机将其分为两组,每组32名。两组均给予相同的常规抗炎平喘治疗,对照组给予溴己新口服,甲基泼尼松龙静滴。观察组予以加用复方硫酸沙丁胺醇气雾剂、地塞米松及氨溴索雾化吸入。在入院一周评估患者喘憋改善情况、肺部体征及呼吸困难评分、不良反应等各个指标。结果:复方硫酸沙丁胺醇气雾剂联合氨溴索、地塞米松雾化吸入治疗AECOPD能更快控制病情,减少住院时间。不良反应除引起口腔霉菌感染及肌肉震颤无明显差异外,其它差异有显著性(p<0.01)。
OBJECTIVE: To observe the curative effect of compound salbutamol sulfate aerosol combined with ambroxol and dexamethasone nebulization in patients with AECOPD (AECOPD is acute exacerbation of chronic obstructive pulmonary emphysema). Methods: Sixty-four patients with acute exacerbation of chronic obstructive pulmonary emphysema were enrolled and randomly divided into two groups of 32. Both groups were given the same conventional anti-inflammatory and antiasthmatic treatment, the control group was given bromhexine orally, intravenous methylprednisolone. The observation group was given compound salbutamol sulfate aerosol, dexamethasone and ambroxol inhalation. A week in hospital assessment of patients with wheezing to improve the situation, lung signs and dyspnea score, adverse reactions and other indicators. Results: Compound salbutamol sulfate aerosol combined with ambroxol and dexamethasone aerosol inhalation for AECOPD can control the disease faster and reduce hospitalization time. Adverse reactions in addition to causing oral mold infection and muscle tremor no significant difference, the other differences were significant (p <0.01).