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目的观察不同浓度的高碘对大鼠血清中同型半胱氨酸(HCY)及丙二醛(MDA)的影响。方法将32只断乳1个月左右远交封闭群的SPF/VAF级Wistar大鼠随机分为4组,分别为正常对照(NC,水碘含量为5μg/L)组和10倍碘(10 HI,2 000μg/L)组、50倍碘(50 HI,10 000μg/L)组、100倍碘(100 HI,20 000μg/L)组,每组8只,雌雄各半。采用自由饮水方式进行染毒,连续喂养6个月。染毒结束后,测定血清同型半胱氨酸和丙二醛含量。结果与NC组相比,不论雄性还是雌性,50、100 HI组大鼠血清中HCY和MDA含量均较高,差异有统计学意义(P<0.05或P<0.01)。不同性别大鼠血清中HCY和MDA含量间比较,差异无统计学意义。结论 10倍高碘对大鼠血清中同型半胱氨酸及丙二醛未有影响,而50、100倍高碘可引起大鼠血清中同型半胱氨酸及丙二醛含量上升。
Objective To observe the effect of different concentrations of high iodine on serum homocysteine (HCY) and malondialdehyde (MDA) in rats. Methods 32 SPF / VAF Wistar rats were randomly divided into 4 groups: normal control group (NC, water iodine 5μg / L) and 10 times iodine (10) HI, 2 000 μg / L), 50 times iodine (50 000 μg / L) and 100 times iodine (100 000 000 μg / L). Adopt free drinking water to carry on poisoning, continuous feeding for 6 months. After the exposure, serum homocysteine and malondialdehyde levels were determined. Results Compared with NC group, the contents of HCY and MDA in serum of 50,100 HI group were higher than those of NC group (P <0.05 or P <0.01). There was no significant difference in serum HCY and MDA between different sexes. Conclusions 10-fold high iodine has no effect on serum homocysteine and malondialdehyde in rats, while 50,100-fold high iodine can cause the increase of serum homocysteine and malondialdehyde in rats.