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目的 ;验证正常大鼠丘脑底核神经元放电模式中存在随机共振现象。方法运用全细胞膜片钳技术,对大鼠脑片丘脑底核神经元进行阈下正弦电流刺激,通过叠加不同输入频率正弦电流和不同强度噪声,分析峰峰间期(ISIH)和信噪比(SNRISIH),观察神经元放电特点。结果在单细胞水平证明了在中枢神经系统运动神经元中存在随机共振现象。在中等噪声强度时(约在20~25 pA处),丘脑底核神经元对叠加噪声的阈下周期性刺激存在最佳响应,其信噪比达到峰值;在一定频率范围(约为5~10 Hz),噪声和神经元输出反应之间存在最适匹配,神经元对阈下弱信号的检测提取能力最佳。结论正常大鼠丘脑底核神经元放电模式中存在随机共振现象。
Objectives; To verify the existence of stochastic resonance in normal rat subthalamic nucleus neuronal discharge patterns. Methods Whole-cell patch-clamp technique was used to stimulate subthreshold sinusoidal currents in subthalamic nucleus neurons in rat brains. By superimposing sinusoidal currents with different input frequencies and different intensity noises, the peak-to-peak interphase (ISIH) and signal to noise ratio SNRISIH), observed neuronal discharge characteristics. Results at the single-cell level demonstrated the presence of stochastic resonance in motor neurons of the central nervous system. At medium noise intensity (about 20-25 pA), the subthalamic nucleus neurons have the best response to the subliminal periodic stimulus of superimposed noise with a peak signal-to-noise ratio. At a certain frequency range (about 5 ~ 10 Hz), there is an optimal match between noise and neuron output response, and neurons have the best detection and extraction ability for subthreshold weak signals. Conclusion There is a phenomenon of stochastic resonance in the discharge model of subthalamic nucleus neurons in normal rats.