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格林-巴利综合征即急性特发性感染性多神经根炎病变(AIP),其发病率为每年每百万人口中占1～1.5,这一数字在世界各国无多大差别。因此,本病并非常见,然而是周围神经病变的较严重的原因之一,并具有很高的病死率。从病理上讲,整个周围神经系统特别是脊神经根存在多处与局部炎性细胞浸润灶相关的病理性脱髓鞘区。髓鞘从轴索开始被巨噬细胞吞噬剥离。这些组织学的特点说明细胞介导的作用,并具有伴随的免疫学证据,另一方面存在体液因素的作用,包括AIP病人的血清所见。假如将血清加入到组织培养中或接种于动物的神经内,会产生脱髓鞘变化。所以,用血浆置换法治疗AIP便成为一个探讨的
The Guillain-Barre syndrome, an acute idiopathic polyneuritis root infection (AIP), has a prevalence of 1 to 1.5 per million inhabitants per year, a figure that does not differ widely in many countries of the world. Therefore, the disease is not common, but it is one of the more serious causes of peripheral neuropathy, and has a high case fatality rate. Pathologically speaking, the entire peripheral nervous system, especially the spinal nerve root there are many pathological demyelination associated with local inflammatory cell infiltration focus. Myelin from the axon phagocytosis by macrophages. These histological features illustrate cell-mediated effects with accompanying immunological evidence and, on the other hand, the role of humoral factors, including those seen in the serum of AIP patients. If serum is added to tissue culture or inoculated into the animal’s nerve, demyelination may occur. Therefore, the use of plasmapheresis AIP treatment has become a discussion