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目的探讨六味地黄丸治疗2型糖尿病肾阴虚证患者的作用机理。方法将133例2型糖尿病肾阴虚证患者随机分为治疗组(91例)和对照组(42例),对照组给予基础治疗(饮食体重控制、加强运动、口服降糖药物),治疗组在基础治疗同时加服六味地黄丸(每次10粒,每日3次),疗程为12周,测定两组患者治疗前后血清脂联素、高敏C反应蛋白(hs-CRP)、空腹血糖(FBG)、糖化血红蛋白(HbA1c)、血脂、肾功能的变化。结果与治疗前比较,对照组治疗后HbA1c、FBG及甘油三酯(TG)明显下降(P<0.05或P<0.01),治疗组治疗后hs-CRP、血肌酐(SCr)、HbA1c、FBG、TG及低密度脂蛋白胆固醇(LDLC)明显下降,脂联素明显升高(P<0.05或P<0.01);治疗后治疗组较对照组hs-CRP、HbA1c、FBG及TG明显下降、脂联素明显升高,差异有统计学意义(P<0.05)。结论六味地黄丸能明显升高2型糖尿病肾阴虚证患者血清脂联素水平,降低hs-CRP、FBG、TG及LDL-C的水平。
Objective To investigate the mechanism of Liuweidihuangwan in treating type 2 diabetic patients with kidney yin deficiency. Methods A total of 133 patients with type 2 diabetes mellitus and kidney yin deficiency were randomly divided into treatment group (n = 91) and control group (n = 42). The control group was given basic treatment (diet weight control, exercise and oral hypoglycemic drugs) At the same time, add Liuweidihuang Pill (10 capsules, 3 times a day) for 12 weeks. The levels of serum adiponectin, high-sensitivity C-reactive protein (hs-CRP), fasting blood glucose FBG), glycosylated hemoglobin (HbA1c), blood lipid, renal function changes. Results Compared with those before treatment, the levels of HbA1c, FBG and triglyceride (TG) in the control group decreased significantly (P <0.05 or P <0.01), and the levels of hs-CRP, SCr, HbA1c, FBG, (P <0.05 or P <0.01). After treatment, the levels of hs-CRP, HbA1c, FBG and TG in the treatment group were significantly lower than those in the control group, and the levels of TG, LDL and LDL were significantly decreased Su significantly increased, the difference was statistically significant (P <0.05). Conclusion Liuweidihuangwan can obviously increase the levels of serum adiponectin and reduce the levels of hs-CRP, FBG, TG and LDL-C in type 2 diabetic patients with deficiency of kidney yin.