Correlation between the Xba Ipolymorphism of apoB gene and serumlipid profiles in Li ethnic group

• 作 者: Yue-Li Liu Yun-Bo Zhang Ying Li Rui-Lian Ma Wang-Wei Cai Li Lin-Jiang Tian-Song Wang Zhen Yao
• 机 构: School of Pharmacy, Hainan Medical College, Haikou 571101, P. R. China“,”Department of Cardiology, P
• 出 处: 亚太热带医药杂志（英文版）
• 发表日期: 2014年1期
• 关键词: Xba I polymorphism ApoB gene Lipid profile Li ethnic group

Objective: To study correlation between the XbaⅠpolymorphism of apoB gene and plasma lipid profiles in Li ethnic group. Methods: Total 151 cases of healthy Li people were recruited randomly by cluster sampling and 200 Han people were recruited as control; blood was drawn to analyze XbaⅠpolymorphism distribution of apoB gene and serum lipid levels. Results: There were lower serum total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) levels in serum of Li people; while, high density lipoprotein cholesterol (HDL-C), X-/X+ genotype and X+ allele frequencies exhibited higher levels than Han people. Interestingly, HDL-C level was reduced, while LDL-C level was enhanced in subjects carrying heterozygous (X-/X+) genotype compared to homozygous (X-/X-) genotype. Additionally, there were no difference in serum level of triglyceride, TC, apoprotein A (apo A) and apoprotein B (apo B) between Li and Han people, the same results were showed between X-/X+ and X-/X- genotype carriers. Conclusions: XbaⅠpolymorphism of apoB gene is correlated to the profiles of serum lipid level, X-/X+ genotype carriers are phenotyped with higher LDL-C level and lower level of HDL-C in Li ethnic group.