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目的探讨染色体多态性与复发性流产之间的临床效应。方法统计分析2009年6月至2015年6月在我院妇产科门诊咨询的2450例复发性流产夫妇(复发性流产组)为研究对象,采用常规方法细胞培养G显带、C显带及N显带检测染色体核型及染色体多态性,同时选取670对(1340例)无流产史,足月分娩过的正常夫妇作为对照组。结果复发性流产组的夫妇中染色体多态性的检出率5.4%(133/2450)高于对照组的1.5%(20/1340),差异有统计学意义(P<0.05)。复发性流产组中D、G组短臂增长、次缢痕增加(包括1、9和16号染色体)、Y染色体次缢痕增加或减少和9号染色体臂间倒位的染色体多态性均高于对照组,差异有统计学意义(P<0.05)。结论染色体多态性可能与复发性流产存在一定的关系,临床遗传咨询需重视复发性流产患者中染色体多态性的因素。
Objective To explore the clinical effect of chromosome polymorphism and recurrent spontaneous abortion. Methods Statistical analysis of 2450 cases of recurrent spontaneous abortion (recurrent spontaneous abortion) consultation in obstetrics and gynecology outpatient consultation in our hospital from June 2009 to June 2015 were used as research object. The G-band, C-band, N banding was used to detect the karyotype and chromosome polymorphism. At the same time, 670 pairs (1340 cases) with no history of abortion and normal term delivery were used as the control group. Results The detection rate of chromosome polymorphism in couple with recurrent spontaneous abortion was 5.4% (133/2450) higher than that in control group (1.5%, 20/1340), the difference was statistically significant (P <0.05). In the recurrent spontaneous abortion group, the short arm of group D and G increased, the number of secondary marks increased (including chromosomes 1, 9 and 16), the number of chromosomes with Y markings increased or decreased and chromosome 9 polymorphism Higher than the control group, the difference was statistically significant (P <0.05). Conclusion Chromosomal polymorphism may be related to recurrent spontaneous abortion. Clinical genetic counseling should pay more attention to the factors of chromosome polymorphism in patients with recurrent spontaneous abortion.