论文部分内容阅读
目的评价磁共振弥散成像(DWI)和灌注成像(PWI)技术在超早期脑梗死中的诊断价值。方法新西兰白兔42只,随机分为7组,其中6组为实验组,1组为假手术组。采用改良O’Brein法闭塞兔一侧大脑中动脉制作局灶性脑缺血模型,对照组仅暴露同侧大脑中动脉,不予电凝。术后0.5、1、2、3、4、6 h不同时间段进行MRI扫描。结果常规MR序列显示缺血病灶明显晚于DWI和PWI。随着时间延长病灶各参数有特征性变化规律。在DWI和PWI中缺血区体积均随时间的延长不断扩大,两者不匹配区随时间延长逐渐缩小。结论DWI和PWI在诊断超早期脑梗死上优于常规MR序列。
Objective To evaluate the diagnostic value of diffusion-weighted magnetic resonance imaging (DWI) and perfusion imaging (PWI) in patients with ultra-early cerebral infarction. Methods Forty-two New Zealand white rabbits were randomly divided into 7 groups, of which 6 were experimental group and 1 group were sham operation group. The model of focal cerebral ischemia was established by occlusion of rabbit middle cerebral artery with modified O’Brein method. The control group only exposed the ipsilateral middle cerebral artery without coagulation. MRI scan was performed at different time points after 0.5,1,2,3,4,6 h. Results The MR sequence showed ischemic lesions were significantly later than DWI and PWI. With the extension of time the parameters of the lesions have characteristic changes. The volume of ischemic area in DWI and PWI both increased with the extension of time, and the area of mismatch between them gradually narrowed with time. Conclusion DWI and PWI are superior to conventional MR in the diagnosis of early-stage cerebral infarction.