论文部分内容阅读
[目的]总结促纤维增生性恶性黑色素瘤的临床病理学特征。[方法]对5例促纤维增生性恶性黑色素瘤术后标本行HE、免疫组织化学(En Vision法)染色、电镜观察及随访。[结果]光镜下见肿瘤性梭形黑色素细胞位于成熟的胶原束内或之间,梭形肿瘤细胞排列混乱,肿瘤细胞胞质内几乎未见黑色素。免疫组化示肿瘤细胞S-100、NSE及SMA阳性。电镜示成纤维细胞样的肿瘤细胞。[结论]促纤维增生性恶性黑色素瘤是一种罕见疾病,临床易与其它梭形细胞肿瘤混淆,特征性的病理组织学及免疫组织化学特征有助于诊断及鉴别诊断。
[Objective] To summarize the clinicopathological features of fibromic malignant melanoma. [Method] The specimens of 5 cases of proliferative malignant melanoma were stained with HE and immunohistochemistry (En Vision method), observed by electron microscope and followed up. [Result] The tumorous spindle-shaped melanocytes were located in or between the mature collagen bundles under the light microscope. The arrangement of spindle-shaped tumor cells was chaotic, and there was almost no melanin in the cytoplasm of tumor cells. Immunohistochemistry showed tumor cells S-100, NSE and SMA positive. Electron microscopy showed fibroblast-like tumor cells. [Conclusion] Fibrosis hyperplastic malignant melanoma is a rare disease which is easily confused with other spindle cell tumors. The characteristic histopathological and immunohistochemical features are helpful for the diagnosis and differential diagnosis.