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目的探讨654-2和活血化瘀中药的驱汞作用。方法以二巯基丁二酸钠+654-2或用具活血化瘀及金属络合作用的中药复方作汞吸入兔治疗观察,并作临床驱汞疗效分析(观察组),分别与二流基丁二酸钠驱汞(对照组)作对照。结果观察组疗效显著优于对照组,表现为治疗后微循环改变恢复正常,电镜示兔脑、肾的组织细胞损伤已修复,中毒症状解除,且未见毒副反应。而对照组在症状、微循环改变、细胞损伤等方面均无明显的改善,且有头昏、乏力、纳减等副作用、结论驱汞同时改善微循环可作为优化汞毒害防治的新疗法,可予进一步探讨并推广应用。
Objective To explore the role of excretion of mercury in 654-2 and traditional Chinese medicine. Methods Sodium dimercaptosuccinate + 654-2 or Chinese herbal compound with the function of activating blood circulation to remove blood stasis and metal complex was used to treat rabbits with Mercury inhalation, and the effect of clinical excretion of mercury was observed (observation group) Sodium excretion of mercury (control group) as a control. Results The observation group had significantly better curative effect than the control group. The changes of microcirculation returned to normal after the treatment. Electron microscopy showed that the tissue injury of the brain and kidney in the rabbit had been repaired and the symptoms of poisoning were relieved without toxic or side effects. The control group showed no significant improvement in symptoms, changes in microcirculation and cell injury, and had the side effects of dizziness, fatigue, and nadir reduction. Conclusions Excretion of mercury while improving microcirculation may be used as a new therapy to optimize the prevention and control of mercury poisoning. To further explore and promote the application.