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于大鼠妊娠第7天,每侧子宫角内注入1.5mg醋酸棉酚混悬液(0.15ml),对照组注入等量溶剂。于妊娠第16天处死大鼠。处死前取血测定血清孕酮,处死后取卵巢,称重及测△~5-3β-羟甾脱氢酶的活性,同时记录妊娠动物数及正常胚胎数。结果表明,醋酸棉酚对大鼠具有明显的抗早孕作用,止孕率达84.6%。对血清孕酮水平及△~5-3β-羟甾脱氢酶的活性均无显著影响。以上结果提示,宫内用醋酸棉酚抗早孕的作用有可能是局部性的。
On the 7th day of gestation of rats, 1.5 mg of gossypol acetic acid suspension (0.15 ml) was injected into each uterine horn, and the control group was injected with equal amount of solvent. The rats were sacrificed on the 16th day of pregnancy. Serum progesterone was measured before sacrifice and the ovaries were taken after sacrifice. The activity of △~5-3β-hydroxysteroid dehydrogenase was measured, and the number of pregnant animals and the number of normal embryos were recorded. The results showed that gossypol acetic acid had a significant anti-pregnancy effect in rats and the rate of pregnancy inhibition was 84.6%. There was no significant effect on serum progesterone levels and △~5-3β-hydroxysteroid dehydrogenase activity. The above results suggest that the effect of intrauterine gossypol acetate on early pregnancy may be localized.