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本研究选用72周龄Wistar大鼠随机等量分为对照组，白天12小时加力组和夜晚12小时加力组。用放射免疫法测定髁突内源性cAMP含量并用余弦法对所得数据进行分析，结果发现：大鼠自然状态下,髁突内源性cAMP存在昼夜节律变化，调整中值112．17pmol／g，振幅12．00pmol／g，峰值相位3：32；白天加力和夜晚加力组，cAMP的昼夜节律并未消失，整条曲线垂直上移，并且白天加力组cAMP调整中值上升大于夜晚加力组。从而得到以下结果和推论：髁突改建程度，昼夜并非均匀一致，而是呈现有规律的波动；在生长发育期，于一昼夜内大鼠髁突生长的峰值期加力，即白天加力能获得最佳矫治效果，最优矫治效率，本研究结果提示，在临床早期矫形治疗中，可选择矫治的最佳介入时间来缩短疗程，提高矫治效率，即对人类采用夜间（人与大鼠昼夜节律相位差12小时）戴用矫治器可能起到同样的治疗效果。
In this study, 72-week-old Wistar rats were randomly divided into the control group, 12 hours during the day afterburner group and 12 hours at night afterburner group. The content of endogenous cAMP in condyle was determined by radioimmunoassay and the data were analyzed by cosine method. The results showed that there was a circadian rhythm of endogenous cAMP in condylar condyle with a median of 112.17pmol / g, Amplitude 12.00pmol / g, the peak phase 3:32; day afterburner and night afterburner group, circadian rhythm of cAMP did not disappear, the entire curve up vertically, and the day afterburner group cAMP adjustment median rise more than night plus Force group. The following results and inferences were obtained: the condylar reconstruction degree, day and night are not uniform, but showed a regular fluctuations; in the growth and development period, during the whole day and night in rat condylar growth peak force, that is, The best correction effect, the optimal correction efficiency, the results suggest that in the early clinical orthopedic treatment, the best choice of treatment intervention time to shorten the course of treatment, improve the efficiency of correction, that is, human use at night (human and rat circadian rhythm Phase difference of 12 hours) Wear appliances may play the same therapeutic effect.