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本文报道了丁丙诺啡游离碱及其盐酸盐经离体皮肤的渗透作用。丁丙诺啡是一合成的阿片类镇痛剂，临床上用于减轻急、慢性疼痛。研究丁丙诺啡的透皮吸收不仅减少用药次数，而且避免了po时的首过效应。丁丙诺啡游离碱的制备丁丙诺啡游离碱由其盐酸盐制备而得。将一定量盐酸盐溶于
This article reports the penetration of buprenorphine free base and its hydrochloride on isolated skin. Buprenorphine is a synthetic opioid analgesic that is clinically used to relieve acute and chronic pain. Study buprenorphine transdermal absorption not only reduce the frequency of medication, but also to avoid the po first pass effect. Preparation of Buprenorphine Free Base Buprenorphine free base is prepared from its hydrochloride salt. A certain amount of hydrochloride dissolved