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红斑肢痛症是一种原因未明的植物神经系统疾患,主要表现以双足对称性红、肿、热、痛及足背动脉搏动增强为特征.临床治疗多以综合治疗为主,但疗效不佳.现介绍几种临床常用药物治疗红斑肢痛症,以供参考.1 苯噻啶 徐建华用苯噻啶成人30 mg·kg~(-1)·d~(-1),儿童减半,一般在d1～2每晚睡前服 1片(0.5 mg),d 3～4每天中午及晚上各服1片,d5以后每次1片,tid,疗程7～10 d,共治疗18例.用药后肢痛消失时间 3 d者1例,4d7例,6d10例,平均为5d,其他并发体征多在1～2wk消失.有人认为本病可能与体内5-羟色胺(5-HT)代谢亢进和动脉管壁中缓激肽(BKN)的蓄积有关,苯噻啶是一种很强的抗5-HT及抗组胺药物,尚有抑制BKN的致病作用,因而能使扩张的动脉管壁的痛阈降低.2 普鲁卡因 卢德新等以普鲁卡因(皮试阴性者)15mg
Fulminant limb pain is an unexplained autonomic nervous system disorder characterized by bipolar symmetry of redness, swelling, heat, pain and increased dorsalis pedis artery pulsation.Most of the clinical treatments are generalized, but the curative effect is not Good. Now introduce several clinical commonly used drugs for the treatment of erythema pain, for reference .1 Phenylthiidine Xu Jianhua Phenylthiazide adult 30 mg · kg -1 d -1, children in half, Usually d1 ~ 2 every night before bedtime take 1 (0.5 mg), d 3 ~ 4 every day at noon and night each serving 1, d5 after each one, tid, treatment of 7 ~ 10 d, a total of 18 cases. After treatment, pain disappeared in 3 days, 1 case, 4d7 cases, 6d10 cases, with an average of 5d, other concurrent signs disappeared in 1 ~ 2wk. Some people think that this disease may be associated with hyperkinetic 5-HT (5-HT) metabolism and arteries Wall of bradykinin (BKN) accumulation of Phenylthiazide is a strong anti-5-HT and antihistamine drugs, but also inhibit the pathogenic role of BKN, which can make the dilation of the arterial wall Pain threshold decreased .2 procaine Luling new to procaine (skin test negative) 15mg