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目的：探讨和对比不同甲氨蝶呤(MTX)应用方案联合米非司酮治疗异位妊娠的临床疗效和不良反应发生率。方法选取本院确诊为异位妊娠患者80例，随机分为A组和B组，每组40例。其中A组采用一次性给药方式，B组采用分次给药方式。两组均口服同剂量米非司酮。观察治疗7 d后患者的临床有效率和不良反应发生率。结果 A组总有效率为90%；B组总有效率为62.5%，差异有显著统计学意义(P＜0.01)。A组不良反应总发生率为10%(4/40)，与B组的15%(6/40)无显著差异( P＞0.05)。结论甲氨蝶呤一次性给药可有效提高异位妊娠患者的临床疗效，减少不良反应发生率，值得在临床推广应用。“,”Objective To discus and compare the clinical effect and adverse reaction rate of different administrative methods of Methotrexate (MTX) concomitant with Mifepristone on patients with ectopic pregnancy. Methods A total of 80 patients with ectopic pregnancy in out hospital were divided into A group and B group, 40 cases for each group, in which MTX was to A group in 1 time and B group in several times, while Mifepristone was given to both groups in same dosage and administrative method. Clinical effect and adverse reaction rate of both groups were observed and compared after 7-d treatment. Results The total effective rate of A and B groups were 90% and 62.5% respectively, and there was significant difference (P0.05). Conclusion The administration of MTX in 1 tie concomitant with Mifepristone can improve the clinical effect and reduce the adverse reaction rate for patients with ectopic pregnancy, deserving to be widely applied in clinic.