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目的探讨军事演习前后部队官兵血清和胃黏膜中白细胞介素6(interleukin-6,IL-6)的水平及其意义。方法分别采用酶联免疫吸附和免疫组化的方法检测某部60名官兵军事演习前后血清和胃黏膜中IL-6的水平。结果军事演习后官兵血清中IL-6的含量明显高于演习前(P<0.01);IL-6在胃黏膜组织中主要表达于部分间质细胞及腺上皮细胞的胞浆中,演习后其表达明显高于演习前(P<0.01)。结论 IL-6可能中介了军事应激所致的胃黏膜病变。在军事应激早期检测该细胞因子的含量有助于评估发生胃黏膜病变的可能性及严重程度。
Objective To investigate the levels of interleukin-6 (IL-6) in the serum and gastric mucosa of military officers and soldiers before and after the military exercise and their significance. Methods The levels of IL-6 in serum and gastric mucosa of 60 military officers and soldiers before and after the military exercise were detected by enzyme-linked immunosorbent assay (ELISA) and immunohistochemistry respectively. Results The levels of IL-6 in serum of officers and soldiers after military exercises were significantly higher than those before exercise (P <0.01). IL-6 was mainly expressed in the cytoplasm of some stromal cells and glandular epithelial cells in the gastric mucosa. The expression was significantly higher than that before exercise (P <0.01). Conclusion IL-6 may mediate gastric mucosal lesions caused by military stress. The early detection of this cytokine content in military stress helps to assess the likelihood and severity of gastric mucosal lesions.