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尼尔雌醇的原名为炔雌三醇—3—环戊醚(CEE_3)是继雌三醇(E_3)、炔雌三醇(EE_3)之后的又一个对妇女更年期综合征具有良好治疗效果的新合成雌激素,其效果甚至优于EE_3和E_3。作者采用国产硅胶预制高效薄层色谱板对大鼠ip CEE_3后分离分析其血浆和肝匀浆以及尿中原药及其代谢物,并结合双波长薄层扫描技术进行定量测定。实验表明血浆和肝匀浆都可分离得到5种组分,以R_1值由大到小顺序排列为:原药CEE_3、峰Ⅱ、EE_3、峰Ⅳ和E_3.对3种已知组分的定量分析表明:给药后24h内
The original name of nilestriol is ethinylestradiol-3-cyclopentyl ether (CEE_3), which is the second one after estriomethol (E_3) and ethinylestradiol (EE_3) and has a good therapeutic effect on menopausal syndrome New synthetic estrogen, the effect even better than EE_3 and E_3. The authors used domestic silica prefabricated high-performance thin-layer chromatography on the rat ip CEE_3 after separation and analysis of plasma and liver homogenates and urinary drugs and their metabolites, combined with dual-wavelength thin layer scanning technique for quantitative determination. The results showed that 5 components could be separated from plasma and liver homogenate, and the order of R_1 was CEE_3, peak Ⅱ, EE_3, peak Ⅳ and E_3. The quantification of 3 known components Analysis shows that: 24h after administration