论文部分内容阅读
用国产重组人白介素-2（rhIL－2）复制大鼠低血压模型并探讨其机制。24只wistar大鼠随机分成3组（每组n＝幻：正常对照组，IL－2实验组（rhIL－2）和氨基胍（AG）治疗组。结果显示：IL－2可使大鼠提睾肌微动脉扩张及MAP下降，肺、肾、肝组织Evan’sBlue含量明显增加。AG可使rhIL－2引起的低血压回升，微动脉缩小，肺组织Evan’sBlue含量明显下降。提示rhIL－2引起低血压，可能与IL－2诱导NO产生，使血管扩张及通透性增加有关。
Recombinant human interleukin-2 (rhIL-2) was used to replicate rat hypotension and explore its mechanism. Twenty-four wistar rats were randomly divided into 3 groups (n=Gn:normal control group, IL-2 experimental group (rhIL-2) and aminoguanidine (AG) treatment group. The results showed that: IL-2 can make rats The expansion of the testis muscle arteries and MAP decreased, and the Evan’s Blue content in the lung, kidney, and liver tissues increased significantly, AG could increase the hypotension induced by rhIL-2, and the arterioles decreased, and the Evan’s Blue content in the lung tissue decreased significantly, suggesting that rhIL- 2 Hypotension, which may be related to IL-2 induced NO production, is associated with increased vasodilation and increased permeability.