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目的:分析高压氧辅助治疗对下肢静脉曲张伴活动性溃疡患者术后生活质量、溃疡愈合速度及不良反应发生率的影响。方法:选取2017年1月至2018年1月廊坊市人民医院介入血管外科收治的下肢静脉曲张伴活动性溃疡患者96例为研究对象，随机分为对照组48例、观察组48例，2组患者均采用经皮血管瘤腔内药物灌注术＋经皮静脉内激光成型术，对照组患者术后给予常规换药处理和护理干预，观察组患者术后在常规换敷料基础上给予高压氧治疗。比较2组患者临床疗效、生活质量、溃疡愈合情况及不良反应发生率。结果:观察组患者经高压氧治疗后临床总有效率为93.75%，对照组患者常规治疗后临床总有效率为66.67%，2组比较差异具有统计学意义(n P<0.01)；治疗后2组患者生活质量各维度评分均较治疗前明显升高，差异均有统计学意义(n P<0.05)，观察组治疗后生理机能、生理职能、躯体疼痛、活力、情感职能维度评分明显高于对照组，差异均有统计学意义(n P<0.05)；治疗后2组患者溃疡面积均较治疗前缩小，差异均有统计学意义(n P<0.05)，观察组治疗后溃疡面积明显小于对照组，差异有统计学意义(n P<0.05)；观察组患者发生3例耳痛，不良反应总发生率为6.25%，对照组不良反应总发生率为18.75%，2组比较差异具有统计学意义(n P<0.01)。n 结论:高压氧辅助治疗下肢静脉曲张伴活动性溃疡患者临床效果显著，可明显促进溃疡面愈合，降低不良反应发生率，提高患者生活质量。“,”Objective:To investigate the effects of hyperbaric oxygen therapy on postoperative quality of life, ulcer healing, and adverse reaction in patients with varicose veins of lower extremities and active ulcers.Methods:A total of 96 patients with varicose veins of lower extremities and active ulcers admitted to Interventional Vascular Surgery Department of the People’s Hospital of Langfang City from January 2017 to January 2018 were enrolled as study subjects and randomly divided into control group and observation group, each with 48 cases. Both two groups received intra-arterial drug infusion combined with percutaneous transluminal angioplasty. After operation, the control group received routine dressing change and nursing intervention, while the observation group received hyperbaric oxygen therapy on the basis of the treatment in the control group. The clinical efficacy, ulcer healing rate, and adverse reaction rate were compared between the two groups.Results:The total clinical efficacy rate was 93.75% in the observation group, while that in the control group was 66.67%. The difference was statistically significant (n P<0.01). After treatment, the scores of all dimensions of quality of life were increased in both two groups (n P<0.05), moreover, the scores of physiological functions, role-physical, bodily pain, vitality, and role-emotional in the observation group were significantly higher than those in the control group (n P<0.05). After treatment, the ulcer areas in both two groups were reduced (n P<0.05), moreover, the ulcer area in the observation group was significantly smaller than that in the control group (n P<0.05). There were 3 earache cases in the observation group, and the total incidence rate of adverse reactions was 6.25%, which was significantly different from that (18.75%) in the control group (n P<0.05).n Conclusion:Hyperbaric oxygen therapy is effective in treating patients with varicose veins of lower extremities and active ulcers by promoting ulcer healing, reducing the adverse reaction rate, and improving patients’ quality of life.