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目的探讨常规单剂量肺表面活性物质治疗重症胎粪吸入综合症的效果。方法本次病例对象为我院自2014年1月以来所收治的75例重症胎粪吸入综合症患儿,按照随机数字表法将患儿分为常规组和固尔苏组。常规组呼吸机+常规治疗;固尔苏组呼吸机+常规治疗+常规单剂量肺表面活性物质固尔苏治疗。评价:(1)治疗效果;(2)吸氧、机械通气、住院时间;(3)治疗前后氧合指数、动脉/肺泡氧分压。结果 (1)固尔苏组患儿治疗效果显著比常规组高,比较后差异显著,P<0.05;(2)固尔苏组吸氧、机械通气、住院时间显著比常规组短,比较后差异显著,P<0.05;(3)两组治疗前氧合指数、动脉/肺泡氧分压相似,P>0.05;固尔苏组治疗后氧合指数、动脉/肺泡氧分压显著比常规组好,比较后差异显著,P<0.05。结论常规单剂量肺表面活性物质治疗重症胎粪吸入综合症的效果确切,可有效缩短吸氧、机械通气、住院时间,改善患儿生命体征和预后,值得推广。
Objective To investigate the effect of conventional single dose pulmonary surfactant in the treatment of severe meconium aspiration syndrome. Methods The subjects were 75 children with severe meconium aspiration syndrome admitted to our hospital since January 2014. According to the random number table, the children were divided into routine group and Guer Su group. Conventional group ventilator + conventional treatment; solid Seoul Su group ventilator + conventional therapy + conventional single dose of the lung surfactant gel cure. Evaluation: (1) treatment effect; (2) oxygen, mechanical ventilation, hospital stay; (3) before and after treatment oxygenation index, arterial / alveolar oxygen partial pressure. Results (1) The treatment effect of children in Guer Su group was significantly higher than that of the control group (P <0.05). (2) The oxygen inhalation, mechanical ventilation and hospital stay in Guer Su group were significantly shorter than those in the conventional group (P <0.05). (3) Before treatment, the oxygenation index and arterial alveolar oxygen pressure were similar in both groups (P> 0.05). The oxygenation index and arterial alveolar oxygen pressure of Guer Su Su group were significantly lower than those of conventional group Good, significant difference after comparison, P <0.05. Conclusion Conventional single-dose pulmonary surfactant is effective in treating severe meconium aspiration syndrome, which can effectively shorten the oxygen inhalation, mechanical ventilation, hospitalization time, and improve the vital signs and prognosis of children. It is worth to be popularized.